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Schematic model for the interaction of Apn2 with PCNA. In the absence of DNA (top), the conserved PCNA-binding motif of Apn2 and the IDCL of PCNA mediate the interaction between the two proteins. Upon encountering a 3′ primer-template junction (bottom), the C-terminal tail of PCNA becomes engaged in the interaction. The IDCL part of PCNA is shown in black, and the C-terminal portion is shown in gray.
