FIG. 2.

MLL-AFX transformed cells induce acute myeloid leukemias. (A) Representative histology is shown for control and MLL-AFX mice. Paraffin sections were stained with hematoxylin and eosin; blood smears were stained with MGG. In MLL-AFX mice, the spleen and liver were infiltrated with leukemic blasts. Bone marrow was densely packed with a homogeneous population of blasts. Leukemic cells are present in the peripheral blood. (B) Survival curves are shown for cohorts (n = 10) of sublethally irradiated C57BL/6 mice that were injected with MLL-AFX immortalized cells (MLL-AFX), AFX-3′ immortalized cells, or mock injected (control).