FIG. 5.
Development of leukemia in mice transplanted with E2A-HLF/BCL2 or p190Bcr-Abl immortalized cells. (A) Wright-Giemsa-stained preparations of peripheral blood showing leukemia cells with morphological features of lymphoid blasts in animals injected with p190 (left) or BiEH (right) transduced cells. (B) Survival of mice transplanted with cells immortalized by various retroviral constructs. A total of 106 cells from the indicated cell lines were injected into immunocompetent, syngeneic BALB/c mice. Numbers of mice in each cohort are denoted in parentheses.