TABLE 2.
Characteristics of BiEH and p190Bcr-Abl leukemias
| Leukemia | Latency (days) | Phenotype | Splenomegaly | % Blasts in PB | IL-7 dependence | Secondary leukemiaa [no. with leukemia/ no. injected (latency in days)] |
|---|---|---|---|---|---|---|
| BiEH-L1 | 100 | B220+ CD43− BP1+ IgMlo | + | >90 | − | 5/5 (21) |
| BiEH-L2 | 70 | B220+ CD43− BP1+ IgMlo | + | >90 | − | ND |
| BiEH-L3 | 105 | B220+ CD43− BP1+ IgMlo | + | >90 | − | ND |
| BiEH-L4 | 110 | B220+ CD43− BP1+ IgMlo | + | >90 | − | 5/5 (30-40) |
| P190-L1 | 21 | B220+ CD43+ BP1+ IgM− | + | >90 | − | 5/5 (17) |
| P190-L2 | 22 | B220+ CD43+ BP1+ IgM− | + | >90 | − | ND |
| P190-L3 | 22 | B220+ CD43+ BP1+ IgM− | + | >90 | − | ND |
| P190-L4 | 22 | B220+ CD43+ BP1+ IgM− | + | >90 | − | ND |
a
That is, 106 cells were injected i.v. into nonirradiated syngeneic recipients. ND, not determined.