TABLE 3.
Effect of a high-fat, high-cholesterol (HFHC) diet for 7 wk on blood biochemistry in all 21 baboons1
| Variables | Baseline diet | HFHC diet | P2 |
|---|---|---|---|
| Total cholesterol (mg/dL) | 113.1 ± 6.2 | 207.8 ± 14.2 | 0.0013 |
| HDL cholesterol (mg/dL) | 66.2 ± 4.0 | 102.9 ± 5.1 | 0.0013 |
| Non-HDL cholesterol (mg/dL) | 46.9 ± 4.3 | 103.9 ± 13.4 | 0.0013 |
| Ratio of HDL to non-HDL cholesterol | 1.81 ± 0.28 | 1.44 ± 0.25 | 0.936 |
| CRP (mg/dL) | 0.95 ± 0.14 | 0.94 ± 0.19 | 1.000 |
| TAS (mmol/L) | 1.18 ± 0.01 | 1.17 ± 0.02 | 1.000 |
| P-selectin (ng/dL) | 45.7 ± 5.4 | 31.1 ± 2.9 | 0.0013 |
| von Willebrand factor (%) | 191.2 ± 9.6 | 163.3 ± 8.1 | 0.0013 |
| Total CoQ10 (μmol/L) | 0.88 ± 0.06 | 1.27 ± 0.09 | 0.0013 |
| Lipid-standardized α-tocopherol (μmol/L)3 | 11.5 ± 0.77 | 8.9 ± 0.39 | 0.013 |
| Unesterified cholesterol (μmol/L) | 939.6 ± 45.9 | 1397.5 ± 94.2 | 0.0013 |
| Cholesteryl arachidonate (μmol/L) | 174.3 ± 11.6 | 202.7 ± 18.3 | 0.533 |
| Cholesteryl linoleate (μmol/L) | 899.8 ± 65.9 | 1302.1 ± 93.4 | 0.0013 |
1
All values are . CRP, C-reactive protein; TAS, total antioxidant status; CoQ10, coenzyme Q10.
2
Based on a paired t test with Bonferroni’s correction.
3
Calculated by multiplying plasma α-tocopherol concentrations by 1000 and then dividing that value by the corresponding value for unesterified cholesterol concentrations.