TABLE 5.

Effects of antioxidant supplement on serum inflammation, antioxidant status, and endothelial markers among 15 baboons fed different doses of vitamin E with or without coenzyme Q₁₀ (CoQ₁₀) ¹

Diet	Serum CRP	Serum TAS	Serum vWF	Serum P-selectin
	mg/dL	mmol/L	%	ng/dL
Baseline	0.97 ± 0.19	1.18 ± 0.02	187.0 ± 10.12	48.8 ± 78.22
HFHC	0.91 ± 0.21	1.16 ± 0.02	161.9 ± 9.0	32.9 ± 3.7
HFHC-E	0.43 ± 0.063	1.24 ± 0.024	149.3 ± 9.3	37.3 ± 4.8
HFHC-EQ	0.28 ± 0.035	1.26 ± 0.01d4	150.0 ± 10.0	34.1 ± 3.8

¹All values are $\overline{x}\pm \text{SEM}$. HFHC, high-fat, high-cholesterol diet; HFHC-E, HFHC diet with vitamin E supplementation; HFHC-EQ, HFHC diet with vitamin E and CoQ₁₀ cosupplementation; CRP, C-reactive protein; TAS, total antioxidant status; vWF: von Willebrand factor. Baboons supplemented with 250, 500, and 1000 IU/kg diet had similar proportions of increases in plasma α-tocopherol concentrations, so those 3 groups of baboons were combined for the analyses. All comparisons were made against the concentrations during the HFHC diet (paired t test).

²Bonferroni corrected, P = 0.02 (standard paired t test, P values × number of variables tested = 0.005 × 4).

³Bonferroni corrected, P = 0.188 (= 0.047 × 4 = 0.188).

⁴Bonferroni corrected, P = 0.004 (= 0.001 × 4).

⁵Bonferroni corrected, P = 0.036 (= 0.009 × 4).