FIG. 2.

Macroscopic analysis of calnexin gene-deficient mice. (a) Calnexin gene knockout mice are significantly thinner and smaller than their littermates. (b) (Top) Weights of 27 wild-type and 27 calnexin gene-deficient mice, aged 15 to 140 days. At any given time point, calnexin gene-deficient mice are much lighter (about one-third) than their littermates. (Bottom) In addition, calnexin gene knockout mice are shorter than their littermate controls. Shown are lengths of 15 cnx^−/− mice and their littermates, also aged 15 to 140 days. Calnexin gene knockouts are about 10% shorter than control mice. Although the length difference is significant, it is not as profound as the inability to gain weight.