FIG. 4.

Loss of large myelinated nerve fibers correlates with severity of phenotype. (a) Average sizes of the sciatic nerve, small-fiber area, and large-fiber area. The large error bars result from age and sex variations. (b) Average sizes of the sciatic nerve, small-fiber area, and large-fiber area for two sets of one wild-type (wt) and one calnexin gene-deficient mouse at the age of 60 days. (Left) The knockout mouse showed a severe phenotype. (Right) The knockout mouse still showed symptoms of loss of calnexin, but they were less prominent, suggesting that progression of the loss of large myelinated fibers worsens the truncal ataxia and motor disorders seen in these mice.