TABLE 3.

Total numbers of large and small nerve fibers in the sciatic nerves of wild-type and calnexin gene-deficient mice^a

Nerve fibers	No. in:
	Wild-type mice	Calnexin gene knockout mice
		Mild phenotype	Severe phenotypeb
Total	1,981 ± 452	1,703 ± 152	1,370 ± 181
Large	1,085 ± 423	685 ± 94	350 ± 148
Small	896 ± 94	1,018 ± 120	1,020 ± 325

^an = 3. This table shows that the total number of nerve fibers in cnx^−/− mice is reduced to a level of about 70% of that in the wild type and that this loss is caused by a profound reduction in the number of large fibers (to 30% of the wild-type level) while the number of small fibers is slightly increased.

^bE.g., truncal ataxia.