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. 2006 Feb;17(2):623–633. doi: 10.1091/mbc.E05-07-0631

Figure 1.

Figure 1.

GrB and pfn-mediated DNA fragmentation is MPR-independent, but grB- and AdV-mediated DNA fragmentation is MPR-dependent. Jurkat cells were treated with apoptotic stimuli, in the presence or absence of 20 mM M6P. DNA fragmentation was assessed after 3 h, by TUNEL labeling and flow cytometry analysis. (A) Cells were treated with the indicated concentrations of grB, along with AdV. (B) Cells were treated with 500 ng/ml purified grB and the indicated dilutions of purified pfn. Data represent the mean ± SD of six (A) or five (B) separate experiments (** 0.001 < p < 0.01; *** p < 0.001).