Abbreviation	Definition
ADC	antibody–drug conjugate
BCG	bacillus Calmette–Guérin
CGP	comprehensive genomic profiling
CI	confidence interval
CPS	combined positive score
DAB	diaminobenzidine
dd-MVAC	dose-dense methotrexate, vinblastine, doxorubicin and cisplatin
ECOG	Eastern Cooperative Oncology Group
EV	enfortumab vedotin
FDR	false discovery rate
FFPE	formalin-fixed paraffin-embedded
HR	hazard ratio
ICI	immune checkpoint inhibitor
IHC	immunohistochemistry
IQR	interquartile range
ITE	impossible to evaluate
la/mUC	locally advanced or metastatic urothelial carcinoma
MIBC	muscle-invasive bladder cancer
MSI	microsatellite instability
NAC	neoadjuvant chemotherapy
OS	overall survival
PBC	platinum-based chemotherapy
pCR	pathologic complete response
RFS	recurrence-free survival
RT	radiotherapy
TC	tumour cell (score)
TIL	tumour-infiltrating lymphocyte
TMB	tumour mutational burden
TSO-500	TruSight Oncology 500
TURBT	transurethral resection of bladder tumour
UC	urothelial carcinoma
UTUC	upper-tract urothelial carcinoma
VAF	variant allele frequency
VUS	variant of uncertain significance
WES	whole-exome sequencing