Figure 4.

Comparison of GO functional categories that are significantly enriched in subsets of stress genes in C. albicans, S. cerevisiae, and S. pombe. Functional categories that are significantly overrepresented in core, oxidative, osmotic, heavy metal, and heat stress genes sets from C. albicans, S. cerevisiae, and S. pombe were identified using gene ontology (GO) resources at SGD (www.yeastgenome.org/GOContents.shtml). The statistical significance of this enrichment is presented. The list of functional categories was simplified by removing functionally redundant categories and weak probability groups with no clear significance in the response. Core stress genes (CSR) are described in Supplementary Data (Yeast CSRs). Environmental stress response genes (ESR) were as defined by Gasch et al. (2000) and Chen et al. (2003). C. albicans oxidative (XS), osmotic (OS), and heavy metal stress genes (Cd) are defined in this study. S. pombe stress genes were from Chen et al. (2003) (15 min in 0.5 mM H₂O₂, 1 M sorbitol, 0.5 mM CdSO₄,). S. cerevisiae oxidative stress genes were from Gasch et al. (2000) (10 min, 0.32 mM H₂O₂), osmotic stress genes were from O'Rourke and Herskowitz (2004) (10 min, 0.5 M KCl), and heavy metal stress genes were from Fauchon et al. (2002) (30 min, 1 mM CdSO₄).