Figure 6.

The proportion of gene orthologues that display SAPK-dependent induction in response to oxidative, osmotic, or heavy metal stress in C. albicans, S. cerevisiae, and S. pombe. The set of genes that have orthologues in all three yeasts was identified in a systematic manner (Materials and Methods). From these, those genes that display regulation in response to oxidative, osmotic, or heavy metal stress were selected using the datasets described in Figure 4. The number of genes whose induction was dependent on the SAPK (Hog1 in C. albicans and S. cerevisiae or Sty1 in S. pombe) was then calculated according to the criteria described in Materials and Methods and then expressed as a proportion of the genes that were induced under the same conditions: Ca, C. albicans: Sc, S. cerevisiae; Sp, S. pombe. Note that there are no transcript profiling data that address the role of S. cerevisiae Hog1 during responses to oxidative or heavy metal stresses (nd, no data).