TABLE 2.
Assay performance in the context of different centers
| Center no. | Location | No. of SLE patients/no. of controls | % Sensitivity/% specificity | AUC | PPV/NPV/ TE (%)a |
|---|---|---|---|---|---|
| 1 | Shanghai | 100/100 | 35.0/98.0 | 0.660 | 94.6/60.1/66.5 |
| 2 | Poland | 93/91 | 34.0/100 | 0.913 | 100/59.9/66.8 |
| 3 | Japan | 100/100 | 28.0/98.0 | 0.748 | 93.3/57.6/63 |
| 4 | United States | 100/70 | 26.0/98.7 | 0.739 | 96.3/50/57.1 |
| 5 | Freiburg | 51/259 | 23.3/100.0 | 0.788 | 100/71.7/74 |
| 6 | Denmark | 44/31 | 20.5/96.8 | 0.550 | 90/46.2/52 |
| 7 | Berlin | 100/87 | 19.0/100 | 0.853 | 100/51.8/56.7 |
| 8 | Mexico | 8295 | 15.7/99 | 0.520 | 92.9/57.6/60.3 |
| 9 | Israel | 77/97 | 11.7/100 | 0.679 | 100/58.8/60.9 |
| 10 | Brazil | 100/83 | 10.0/100.0 | 0.649 | 100/48/50.8 |
| 11 | Canada | 100/100 | 8.0/100.0 | 0.623 | 100/52.1/54 |
| All | 947/1,113 | 21.3/99.3 | 0.667 | 95.6/62.2/65.3 |
a
PPV, positive predictive value; NPV, negative predictive value; TE, test efficiency.