FIG. 3.

(A) Effect of depletion of CD4⁺ cells from PBMC on IFN-γ responses to peptide. Responses to peptides from each of the three antigens identified were shown to be CD4 restricted through BoLA class II. (B) Inhibition of IFN-γ production from CD4⁺ T cells by blocking of BoLA class II processing by monoclonal antibodies against class II subtypes DQ and DR. a.a., amino acid; p, peptide; mAb, monoclonal antibody.