TABLE 1.
In vitro colony formation of bone marrow hematopoietic progenitors from wild-type and p70-deficient littermates in response to various cytokinesa
| Colony type | Cytokine | No. of colonies formed from p70 genotype
|
|
|---|---|---|---|
| +/+ | −/− | ||
| CFU-E | Epo | 121 ± 9 | 100 ± 13 |
| BFU-E | Epo, IL-3 | 27 ± 5 | 25 ± 5 |
| CFU-G | G-CSF | 39 ± 3 | 37 ± 16 |
| CFU-GM | GM-CSF | 27 ± 7 | 33 ± 8 |
| CFU-Mix | IL-3 | 43 ± 12 | 41 ± 10 |
| CFC-Mix | IL-3, IL-6, SCF, Epo | 12 ± 2 | 16 ± 3 |
| CFU-Eos | IL-5 | 37 ± 9 | 29 ± 5 |
| CFU-Meg | Tpo | 11 ± 2 | 13 ± 5 |
| CFU-Mix | SCF | 32 ± 5 | 37 ± 4 |
| Pre-B | IL-7 | 13 ± 4 | 10 ± 2 |
a
Bone marrow cells from four animals of each genotype were prepared for colony assay.