FIG. 3.

Intracellular cystine content (measured as nanomoles of half-cystine per milligram of protein) of various organs. (a) A total of 140 assays were performed, 71 on Ctns^+/+ mice (black bars) and 69 on Ctns^−/− mice (gray bars), from birth to 1 year of age. The cystine content of all tissues of Ctns^−/− mice was significantly increased in comparison to that observed in their wild-type littermates. The number of mice assayed for each tissue is indicated in parentheses. Error bars correspond to the SEM. (b) Graph showing the increase in cystine content of all organs of Ctns^−/− mice with respect to age (semilogarithmic).