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Identification of PD 184352-resistant MEK mutants by using a S. cerevisiae genetic screen. An illustration of MEK gene indicating mutations found in the genetic screen is shown. Native amino acids are marked by an asterisk, with mutations indicated in boldface. Also depicted are the putative MAP kinase binding region (▨), relevant kinase subdomains (░⃞), Raf phosphorylation sites (P), and the lysine residue essential for phosphoryl transfer (K).
