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PD 184352-mediated inhibition of Leu115Pro mutated MEK. Wild-type MEK and the Leu115Pro variant (50 ng) were assayed for in vitro kinase activity against a kinase-inactive form of ERK [GSTERK1(K71R)] in the presence of indicated concentrations of PD 184352. A 100% control value reflects the activity of Raf-activated, untreated samples. The results are an average of four independent experiments.
