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PD 184352 inhibition of MEK mutant alleles identified from the yeast genetic screen
| MEK allele | IC50 (μM)a ± range (n) |
|---|---|
| Wild type | 0.067 ± 0.02 (4) |
| Phe53Ser | 0.048 ± 0.03 (2) |
| Ile103Asn | 0.163 ± 0.07 (2) |
| Leu115Pro | >10 (4) |
| His119Arg | 0.362 ± 0.20 (2) |
| His119Tyr | 0.154 ± 0.01 (2) |
| Gly128Asp | 0.200 ± 0.07 (2) |
| Glu203Lys | 0.074 ± 0.01 (2) |
Inhibition was measured in an in vitro kinase assay as described in Materials and Methods.
