FIGURE 5. Graphs from the literature data showing the similarity of the functional form of tumor size for different outcomes in node-negative (N0) and in node-positive (N+). (A) Cumulative relative-mortality hazard in N0, adapted from Carter.⁹ (B) Log-hazard ratio of recurrence in N+, reprinted from Gray,¹⁰ with permission of the author and the American Statistical Association. (C) Hazard ratio of treatment failure (local, regional, or distant recurrence, or second primary tumor) in N0, reprinted from Bryant,¹¹ with permission of the author and Kluwer Academic Publishers. (D) Log-hazard ratio of recurrence or death in N+. Functional form for tumor size based on the GBSG-2 data, from Willi Sauerbrei.¹³