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. Author manuscript; available in PMC: 2026 Sep 13.
Published in final edited form as: Eur J Med Chem. 2025 Oct 4;301:118228. doi: 10.1016/j.ejmech.2025.118228

Figure 5: RPPA analysis shows reduction of TG2-related proteins upon treatment with compound P374.

Figure 5:

(A) Heatmap of proteins with significant changes between control and P374-treated SKOV3 cells as detected by RPPA. Blue arrow indicates TG2; red arrows highlight TG2-related proteins. n = 2. (B) Pathway analysis of downregulated proteins from RPPA data, performed using Metascape. (C) Pathway analysis of upregulated proteins identified in RPPA data, also performed using Metascape. (D) Effector analysis of downregulated proteins using Metascape. (E) Western blot analysis validating selected targets identified in the RPPA analysis, n=3.