Skip to main content
. Author manuscript; available in PMC: 2026 Sep 13.
Published in final edited form as: Eur J Med Chem. 2025 Oct 4;301:118228. doi: 10.1016/j.ejmech.2025.118228

Figure 7: TG2 transcript is enriched in invasive HGSOC cells in surgical specimens.

Figure 7:

(A) Representative Visium HD TMA FOV highlighting epithelial cells. Scale bar, 500 μm. (B) Top panel: TGM2 transcript expression overlay (blue, log2 scale 0-3) in three representative cores. Middle panel: Corresponding H&E-stained cores. Bottom panels: Higher-magnification views of the boxed regions from the top panels, showing TGM2 transcript overlay on H&E images. Scale bars: top and middle panels, 500 μm; bottom panels, 50 μm. (C) Higher magnification H&E image showing invasive microclusters characterized by ameboid and mesenchymal morphologies, nuclear pleomorphism, and cytologic atypia. (D) Manual annotation of bins containing invasive cells (highlighted in pink) on the H&E image using the 10X Genomics Loupe Browser paint brush tool. Scale bar, 500 μm. (E) Differentially expressed genes enriched in the invasive cell cluster (pink bins in D) compared to all other bins within the FOV.