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Amino acid residues 365 to 545 of EBNA-3C are necessary and sufficient for coactivating activity with EBNA-2. Reporter assay in BJAB cells using p(−512/+72)LMP1p-Luc, 1 μg of pSG5-EBNA-2 (E2), and 2 μg of either pSG5-EBNA-3C (E3C) or the indicated EBNA-3C deletion construct. Relative luciferase activity is indicated. The results are averages of duplicate samples and are representative of at least three independent repetitions. Error bars indicate standard deviations.
