FIGURE 6. Effect of uPA inhibition on KM12L4 CRC cell migration. A, A transwell migration assay was performed on KM12L4 cells with or without the uPA inhibitor amiloride. Amiloride decreased cell migration induced by IGF-I, HGF, and IGF-I + HGF. *P < 0.05 versus control (Student t test); bars, standard error of mean. B, Photographs of migrated cells.