FIGURE 7. Effect of uPA inhibition on KM12L4 CRC cell invasion. A, A transwell invasion assay was performed on KM12L4 cells with or without the uPA inhibitor amiloride. uPA inhibition with amiloride led to a significant decrease in cell invasion mediated by IGF-I, HGF, and IGF-I + HGF. *P < 0.005 versus control (Mann-Whitney U test); bars, standard error of mean. B, Photographs of invaded cells.