FIGURE 1. A, Serum IGF-I levels dropped 3- to 4-fold immediately after burn. Forty days after trauma, IGF-I levels were still significantly decreased compared with normal values. Normal values for unburned, normal age-matched children: IGF-I: 365 ± 15 μg/mL. B, Serum IGFBP-3 was decreased 4-fold compared with normal. Forty days postburn, levels did not reach normal concentrations. Normal levels: IGFBP-3: 2.8 ± 0.9 μg/mL. C, Serum IGFBP-1 was increased by 2-fold during the first 10 days postburn. At 20 days after trauma, levels decreased and reached normal values. Normal levels: IGFBP-1 115 ± 15 μg/mL. D, Serum insulin was decreased immediately after burn. Insulin increased almost 2-fold over the study period. Normal levels: 20 ± 5 IU/mL. E, Serum GH was 4- to 5-fold decreased after the burn trauma. Serum GH demonstrated no recovery over the 40-day study period and remained decreased. Normal levels: GH 8 ± 1 μg/mL.