FIG. 4.

Clinical course of LDV-induced polioencephalomyelitis in mice treated with anti-LDV switch mutants. The clinical course of paralysis was monitored in groups of eight or nine immunosuppressed C58 mice infected with LDV and treated on days 2, 4, and 7 p.i. and then once weekly with NaCl alone or with anti-LDV switch variant-containing ascitic fluids diluted in NaCl to obtain similar antibody concentrations (IgG1, 1/10; IgG2a, 1/1; IgG2b, 1/10; IgG3, 1/5). The clinical score was determined as follows: 1, paresis of one or two legs; 2, paresis of more than two legs; 3, flaccid paralysis of more than two legs; 4, total flaccid paralysis. Mice were sacrificed at stage 4. Results are shown as the mean score ± the standard error.