FIG. 1.

Effect of CD8⁺ T-cell depletions on FV-induced immunosuppression. Plasma samples from H-2^a/b-resistant (A.BY × B10.A)F₁ mice were tested for anti-SRBC antibody titers in plasma at 28 days after infection with 1,500 spleen focus-forming units of FV (26). CD8⁺ T-cell depletions were performed by five intraperitoneal injections of 0.5 ml of supernatant from clone 169.4 MAb starting at the time of infection as previously described (15). The difference between geometric mean (log₂) anti-SRBC titers in infected mice versus infected, CD8-depleted, mice was statistically significant (P < 0.0001 by unpaired t test).