Table 3.
Adverse perinatal outcomes associated with easily recognisable congenital malformations in a cohort of Gambian neonates born following relatively healthy pregnancy
| Congenital malformation, | OR (95% CI) | p-value | ||
|---|---|---|---|---|
| Yes (n = 140) n (%) |
No (n = 6610) n (%) |
|||
| Birth weighta | ||||
| Normal | 129 (2.1) | 5949 (97.9) | 1.04 (0.56–2.15) | 0.90 |
| Low | 11 (2.0) | 527 (98.0) | ||
| Macrosomia | 0 (0.0) | 132 (100.0) | - | |
| 1-min Apgar scoreb | < 0.001 | |||
| Normal | 126 (1.9) | 6366 (98.1) | 1 | |
| Low | 14 (5.8) | 229 (94.2) | 3.09 (1.62–5.48) | |
| 5-min Apgar scorec | < 0.001 | |||
| Normal | 134 (2.0) | 6547 (98.0) | 1 | |
| Low | 6 (11.1) | 48 (88.9) | 6.10 (2.10–14.62) | |
| Admission | < 0.001 | |||
| No | 112 (1.8) | 6256 (98.2) | 1 | |
| Yes | 28 (7.3) | 354 (92.7) | 4.42 (2.77–6.83) | |
| Death within 24 h after delivery | < 0.001 | |||
| No | 135 (2.0) | 6605 (98.0) | 1 | |
| Yes | 5 (50.0) | 5 (50.0) | 48.75 (11.08–215.62) | |
| Death between 24 h and 28days | < 0.001 | |||
| No | 121 (1.9) | 6301 (98.1) | 1 | |
| Yes | 10 (16.7) | 50 (83.3) | 10.40 (4.60–21.39) | |
| Overall death on day 28 | < 0.001 | |||
| No | 121 (1.9) | 6301 (98.1) | 1 | |
| Yes | 15 (21.4) | 55 (78.6) | 14.18 (7.23–26.33) | |
abirth weight missing in n = 2
b1-min Apgar score missing in n = 15
c5-min Apgar score missing in n = 15
dSurvival status on day 28 missing in n = 258