Figure 1.

Schematic representation of the HpOtx gene and the two mRNAs generated from it by differential promoter utilization and alternative splicing (18). The rectangles above the straight line with 5′ and 3′ demarcations indicate exons, and shaded areas within them correspond to ORFs. The double inclined lines connecting the rectangles depict the splicing pattern of the intervening introns. The nucleotide sequences around the E-box (CACGTG) and the transcriptional initiation site (marked with arrows) are shown for both HpOtxL and HpOtxE.