FIGURE 6. Effects of osteonectin on pancreatic cancer cell invasion. A, Colo-357 cells were incubated with exogenous osteonectin (5μg/ml) for 24 hours. B, Panc-1 cells were transfected with specific osteonectin antisense oligonucleotides for 24 hours. Data are presented as mean ± SEM of 3 independent experiments. C, Exemplary picture of control and osteonectin antisense-treated Panc-1 cells. *P < 0.05.