FIGURE 7. Effects of osteonectin on the expression of MMP-2, p21, and VEGF. Colo-357 cells were incubated with exogenous osteonectin (5 μg/mL) for the indicated time (left panel). Panc-1 pancreatic cancer cells were transfected with specific osteonectin antisense oligonucleotides for the indicated time (right panel). Data are presented as mean ± SEM of 3 independent experiments. *P < 0.05.