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. 2002 Feb;76(3):1089–1099. doi: 10.1128/JVI.76.3.1089-1099.2002

FIG. 3.

FIG. 3.

Replication of rB/HPIV3-RSV subgroup A (panels A) and subgroup B (panels B) chimeras in the respiratory tract of rhesus monkeys. Monkeys were inoculated with one of the indicated rB/HPIV3-RSV chimeras, rB/HPIV3, or rHPIV3, as described in the text. The number (n) of animals in each group is indicated in parentheses. Mean daily titers in NP swab and TL fluid were determined by serial dilution on LLC-MK2 cell cultures, and the presence of virus in the culture was determined by hemadsorption. Titers are expressed as mean TCID50 per milliliter, and the detection limit was 10 TCID50/ml. Titers for rB/HPIV3-RSV subgroup A chimeras are shown in panels A, and those for subgroup B chimeras are shown in panels B. Top panels represent NP swabs (upper respiratory tract [URT]), and bottom panels represent TLs (lower respiratory tract [LRT]). The titers for the rHPIV3 and rB/HPIV3 viruses are included in both graphs for comparison. Specimens in which virus was not detected were assigned a value of 100.5 TCID50/ml.