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(Opposite and above) Heterogeneity of methylation status of the entire CpG island among cell lines or alleles. All 116 CpG sites in the predicted CpG island region in SW1116 (A), T24 (B), HSC41 (C) and Li21 (D) cell lines were analyzed by bisulfite genomic sequencing for methylation status. White and black circles denote unmethylated and methylated CpG sites, respectively (not to scale). Numbers indicate specific plasmid clone.
