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Structures of hydrazide oligonucleotides. Monohydrazide A is obtained from phosphoramidite 6 (deprotection protocol I) and 11 (deprotection protocol II); dihydrazide B is generated from phosphoramidite 10 (deprotection protocol I) and 12 (deprotection protocol II); bis-(dihydrazide) C from 12 in conjunction with branching amidite (12) (deprotection protocol II); tetrahydrazide D is obtained from amidite 16 (deprotection protocol II).
