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. 2026 Sep 3;17:1906472. doi: 10.3389/fneur.2026.1906472

Table 2.

Comparison of PVH and DWMH grades between the PFO group and control group.

Variables PFO group (n = 120) Control group (n = 121) Z/χ2 p-value
PVH [n (%)] 35.740 <0.001
Grade 0 26 (21.7%) 63 (52.1%)
Grade 1 61 (50.8%) 52 (42.9%)
Grade 2 25 (20.8%) 6 (5.0%)
Grade 3 8 (6.7%) 0 (0.0%)
DWMH [n (%)] 101.424 <0.001
Grade 0 16 (13.3%) 87 (71.9%)
Grade 1 50 (41.7%) 32 (26.4%)
Grade 2 28 (23.3%) 2 (1.7%)
Grade 3 26 (21.7%) 0 (0.0%)

PVH, periventricular hyperintensity; DWMH, deep white matter hyperintensity; WMH, white matter hyperintensity.

Data are presented as n (%). The chi-square test was used for comparison of categorical variables between the two groups. Grade 0 indicates no WMH; Grade 3 indicates severe WMH. Control group: Individuals without PFO, matched for age and sex from the same clinical population.