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. 2002 Nov 1;30(21):e113. doi: 10.1093/nar/gnf112

Figure 5.

Figure 5

In vivo examination of microvascular growth in the CAM of 11 day old chicken embryos 48 h after pBM43-based lentiviral VEGF121 transduction. Whereas the regular vessel pattern observed on the CAM remained intact in mock transductions (A), dose-dependent angiogenic response resulted in increased vascular density and atypical (brush- and delta-like) endpoint patterns following spotting of 0.5 × 106 c.f.u./ml (producing 3.4 ± 0.3 ng/ml VEFF121 in 48 h) (B), 3 × 106 c.f.u./ml (producing 21.2 ± 1.7 ng/ml VEGF121 in 48 h) or i.v. injection of 1.5 × 106 c.f.u./ml (producing 10.6 ± 0.9 ng/ml VEGF121 in 48 h) (C) (magnification 25×).