TABLE 1.

Specificity constants for wild-type HIV PR with peptide substrates

Substrate no.	Compositiona	kcat/Km (M−1 s−1)
1	Abz-TIn∼F (NO2) QR-NH2	280,000 ± 40,000
2	Ac-RKSLIL∼ACC	33.8 ± 7.1
3	Ac-RKSLIM∼ACC	477 ± 124
4	Ac-RKDLIM∼ACC	103 ± 7.2
5	Ac-RKDWIM∼ACC	104 ± 26.7
6	Ac-RKDLDM∼ACC	< 0.2
7	Ac-RKDLIn∼ACC	26.1 ± 1.4
8	Ac-RKSLIn∼ACC	220 ± 1.7
9	Ac-RKSLAn∼ACC	53.1 ± 28.1
10	Ac-RKSLVn∼ACC	296 ± 83.4

^aAbz, anthranilyl; n, norleucine.