Table 2.

Study objectives (SOs) and secondary outcomes: data sources, timing of measurement, and planned analyses.

SOs and secondary outcomes		Data source	Timing of measurement	Planned analysis
SO1: quantitative feasibility criteria
	Percentage of Lianeli health questionnaires started and completed, percentage validated by GPsa, number of dedicated consultations, missing data rates before vs after GP review of the health questionnaire, percentage of documented previous screening tests, and patient error rate regarding past examinations	Lianeli CDSSb (automatically recorded metadata)	Continuously recorded from visit 1 to visit 2 (day 1 to day 60)	Descriptive statistics
	GUIDESc patient survey (22 items, including the F-SUSd; Multimedia Appendix 3)	eCRFe or paper-based survey, with the help of research assistants if needed	After visit 2, no later than 90 days after inclusion	Descriptive statistics
	GUIDES PCPf survey (22 items, including the F-SUS) (Multimedia Appendix 4)	eCRF or paper-based survey	At the end of the inclusion period	Descriptive statistics
SO1: qualitative feasibility criteria
GUIDES-related interview canvas (Multimedia Appendix 5)		Semistructured interviews	Patients: within 1 month after study completion; PCPs: within 1 month after the last patient’s last visit at each site	Thematic analysis with deductive (GUIDES domains) and inductive coding; NVivo software
SO2: organizational adjustment and interprofessional collaboration
How centers adapt their organization to implement the Lianeli-based intervention (integration into preventive programs and workflows; patterns of interprofessional collaboration		Semistructured interviews	Patients: within 1 month after study completion; PCPs: within 1 month after the last patient’s last visit at each site	Descriptive qualitative synthesis; organizational model derived from qualitative findings
SO3: explanatory variables for feasibility
	Interprofessional use of Lianeli, defined as the involvement of ≥2 health professionals (including the GP) working with the patient during ADER-F	eCRF by research assistants	Documented during the intervention period (day 1 to day 60)	Exploratory regression model on the primary outcome
	Patient health literacy (HLS-EU16g, French version; range 0-16; inadequate ≤8, problematic >8 and ≤12, adequate >12)	eCRF or paper-based survey, with the help of research assistants if needed	At inclusion (visit 1)	Descriptive statistics
	Social deprivation (EPICESh score; range 0-100; higher=more deprived; threshold of 30.2 commonly used)	eCRF or paper-based survey, with the help of research assistants if needed	At inclusion (visit 1)	Descriptive statistics
SO4 and SO5: exploratory signals related to cancer screening participation
Among patients eligible for at least 1 organized cancer screening (breast, colorectal, or cervical cancer) who are overdue or have never been screened: proportion attending the dedicated screening consultation within 60 d of inclusion; the same proportion is described among patients eligible for opportunistic cancer screenings		Lianeli CDSS (automatically recorded metadata)	Within 60 days of inclusion	Descriptive statistics (hypothesis-generating)

^aGP: general practitioner.

^bCDSS: clinical decision support system.

^cGUIDES: Guideline Implementation with Decision Support.

^dF-SUS: French version of the System Usability Scale.

^eeCRF: electronic case report form.

^fPCP: primary care professional.

^gHLS-EU16: European Health Literacy Survey Questionnaire-16.

^hEPICES: Evaluation of Precarity and Inequalities in Health Examination Centres [Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé].