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TABLE 1.

Frequency of HLA-DR and -DQ alleles in patient groups and controls

MHCa class II allele % Healthy controls (n = 43) % All HCV (n = 58) % Chronic HCV (n = 49) P
All vs controls Chronic vs controls
DRB1
DRB1*01 4.9 10.2 10.2 NS NS
DRB1*15 20.9 6.9 8.2 0.05 (pc = NS) NS
DRB1*16 9.3 8.2 8.2 NS NS
DRB1*03 20.9 20.4 20.4 NS NS
DRB1*04 23.4 34.7 34.7 NS NS
DRB1*11 51.2 25.9 22.4 0.01 (pc = NS) <0.008b
DRB1*12 0 0 0 NS NS
DRB1*13 14.0 32.8 32.7 0.05 (pc = NS) NS
DRB1*14 11.7 22.4 22.4 NS NS
DRB1*07 21.0 22.4 22.4 NS NS
DRB1*08 2.32 2.04 2.04 NS NS
DRB1*10 0 2.04 2.04 NS NS
DRB3* 79.1 74.0 74.0 NS NS
DRB4* 39.5 53.1 53.1 NS NS
DRB5* 32.6 14.3 14.3 NS NS
DQB1
DQB1*02 37.2 36.7 36.7 NS NS
DQB1*03 67.4 51.0 51.0 NS NS
DQB1*04 2.3 2.0 2.0 NS NS
DQB1*05 24.6 38.8 38.8 NS NS
DQB1*06 23.5 36.7 36.7 NS NS
a

MHC, major histocompatibility complex.

b

OR (95% confidence interval) = 0.276 (0.112-0.679).