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. Author manuscript; available in PMC: 2026 Sep 19.
Published in final edited form as: Int J Tuberc Lung Dis. 2025 Oct 31;29(11):495–500. doi: 10.5588/ijtld.24.0637

Table 4.

Mean percentage change in log bedaquiline AUC0–22 (95% CI), associated with clinical covariates after 8 weeks of treatment with bedaquiline.

Covariate Univariate Multivariable
P value P value
HIV −24.7 (−43.1 to −0.3) 0.048 −26.2 (−45.7 to −1.5) 0.040
Age 0.7 (−0.4 to 2.0) 0.305 0.7 (−1.2 to 2.6) 0.458
Sex (referent: male) 33.6 (−2.7 to 83.5) 0.073 12.9 (−23.6 to 66.8) 0.533
Creatinine clearance, μmol/L −0.5 (−1.1 to −0.1) 0.048 −0.4 (−1.0 to 0.3) 0.251
Albumin, g/L 1.3 (−0.5 to 3.7) 0.247 1.6 (−1.4 to 4.5) 0.282
BMI, kg/m2 −4.4 (−9.3 to 0.9) 0.098 −3.6 (−9.1 to 2.1) 0.201

The change in AUC is based on estimates from the linear regression model of the covariates on the log-transformed AUC and expressed as percentage change in AUC for each unit change in covariate.

BMI = body mass index; CI = confidence interval.