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. Author manuscript; available in PMC: 2026 Sep 19.
Published in final edited form as: Int J Tuberc Lung Dis. 2025 Oct 31;29(11):495–500. doi: 10.5588/ijtld.24.0637

Table 5.

Mean percentage change in log delamanid AUC0–23 (95% CI) associated with clinical covariates after 8 weeks of treatment with delamanid.

Covariate Univariate Multivariable
P value P value
HIV −0.075 (−0.291 to 0.141) 0.487 −0.770 (−0.340 to 0.190) 0.562
Age, years −0.003 (−0.012 to 0.006) 0.783 −0.002 (−0.017 to 0.0134) 0.783
Sex (referent: male) 0.007 (−0.242 to 0.257) 0.953 0.045 (−0.256 to 0.346) 0.766
Creatinine clearance, μmol/L 0.001 (−0.003 to 0.005) 0.543 0.001 (−0.006 to 0.007) 0.876
Albumin, g/L 0.004 (−0.015 to 0.022) 0.689 −0.002 (−0.027 to 0.024) 0.890
BMI, kg/m2 0.004 (−0.033 to 0.041) 0.851 0.005 (−0.049 to 0.060) 0.851

The change in AUC is based on estimates from the linear regression model of the covariates on the log-transformed AUC, and expressed as percentage change in AUC for each unit change in covariate.

BMI = body mass index; CI = confidence interval.