Table 2. ChE inhibitory activity of the isatin-derived Schiff bases (imines).
| Code | Compound | AChE | BChE | Ref. | ||
|---|---|---|---|---|---|---|
| IC50 (µM) | Standard IC50 (µM) | IC50 (µM) | Standard IC50 (µM) | |||
| 47 |
|
16.22 ± 0.18 | Galantamine (10.13 ± 0.01) | 20.11 ± 0.12 | Galantamine (22.00 ± 0.01) | 54 |
| 50 |
|
1.60 ± 0.51 | Donepezil (0.016 ± 0.002) | — | — | 55 |
| 57 |
|
0.86 ± 0.03 | Donepezil (22.4 ± 2.1) | 0.66 ± 0.05 | Donepezil (0.21 ± 0.04) | 57 |
| 64 |
|
0.2 ± 0.08 | Donepezil (22.4 ± 2.1) | 0.03 ± 0.03 | Donepezil (0.21 ± 0.04) | 58 |
| 70 |
|
0.034 ± 0.002 | Donepezil (0.084 ± 0.002) | — | — | 59 |
| 74 |
|
1.23 | Tacrine (11.14) | — | — | 61 |
| 78 |
|
0.20 ± 0.05 | Donepezil (2.16 ± 0.12) | 0.90 ± 0.20 | Donepezil (4.5 ± 0.11) | 62 |
| 81(a-b) |
|
(81a) 0.20 ± 0.05 | Donepezil (2.16 ± 0.12) | 0.90 ± 0.20 | Donepezil (4.5 ± 0.11) | 65 |
| — | — | (81a) 0.008 ± 0.002 | Donepezil (8.234 ± 0.628) | |||