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Evolution of coronary physiological assessment techniques.
| Method | Hyperemia | Pressure wire | Diagnostic basis | Contemporary role | |
|---|---|---|---|---|---|
| 1 | 2D-QCA | No | No | Anatomical | Widely available |
| 2 | FFR | Yes | Yes | Physiological | Reference standard |
| 3 | iFR | No | Yes | Physiological | Guideline-supported |
| 4 | QFR | No | No | Computational physiology | Emerging |
| 5 | vFFR | No | No | Computational physiology | Emerging |
| 6 | FFRangio | No | No | Computational physiology | Emerging |
