TABLE 2.
Heterogeneity and ds/dn values
| Patient no. | Avg genetic distancea (10−2 s/nt ± SE)
|
ds/dn ± SEb
|
||
|---|---|---|---|---|
| Blood | Pleura | Blood | Pleura | |
| P50 | 1.69 ± 0.07 | 1.42 ± 0.05 | 2.82 ± 1.14 | 3.78 ± 0.16 |
| P55 | 3.77 ± 0.12 | 3.81 ± 0.11 | 1.65 ± 0.43 | 2.18 ± 0.89 |
| P56 | 3.16 ± 0.11 | 3.15 ± 0.12 | 2.05 ± 0.31 | 4.61 ± 0.94 |
| P57 | 7.65 ± 0.24 | 8.90 ± 0.44 | 0.91 ± 0.08 | 1.51 ± 0.17 |
| P59 | 3.51 ± 0.16 | 4.33 ± 0.16 | 2.55 ± 0.49 | 2.16 ± 0.40 |
| P61 | 3.79 ± 0.20 | 5.30 ± 0.26 | 2.18 ± 0.42 | 1.39 ± 0.42 |
| P63 | 4.42 ± 0.13 | 4.48 ± 0.15 | 1.32 ± 0.13 | 1.38 ± 0.16 |
| P64 | 5.24 ± 0.23 | 5.23 ± 0.25 | 1.31 ± 0.18 | 1.19 ± 0.15 |
a
Average distance was calculated by averaging all the Kimura two-parameter distances of all the quasispecies for each patient.
b
The consensus sequence was determined for each patient, and the average ratio of synonymous to nonsynonymous base substitions (ds/dn) was determined relative to the consensus sequence for each patient.