TABLE 1.
N-terminal VP1 sequences and infectivities of CPV mutants
| Mutant | Sequencea | Ratio of infectious titer (TCID50) and hemagglutinin titerb |
|---|---|---|
| CPV-d | 1-MAPPAKRARRGLV | 122 ± 61 |
| CPVΔVP1 | 1-PAPPAKRARRGLV | <1 |
| CPV-ARRR | 1-MAPPAARARRGLV | 61 ± 41 |
| CPV-KARR | 1-MAPPAKAARRGLV | 36 ± 22 |
| CPV-KRAR | 1-MAPPAKRAARGLV | 4.75 ± 5 |
| CPV-AAAR | 1-MAPPAAAAARGLV | <1 |
a
The sequence shown is the first 13 residues of VP1, showing the substitutions (boldface) prepared in the CPV genomes tested here.
b
Data are shown as ratio ± standard deviation from four separate experiments.