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Net hepatic glycogenolysis and hepatic gluconeogenic flux in 18-hour-fasted conscious dogs during the basal (–40 to 0 minutes) and experimental (0–180 minutes) periods. Basal insulin infusion either continued into the portal vein (circles) or was switched to a peripheral vein (triangles) between 0 and 180 minutes. Mean ± SEM; *P < 0.05 versus portal group.
