TABLE 1.

Comparison of the amino acid differences in the E proteins of ChimeriVax-JE FRhL₃ and ChimeriVax-JE FRhL₅ viruses with published sequences of JE SA14-14-2 vaccine, wild-type JE parental SA14, and JE Nakayama viruses^a

Virus (reference)	Mutation at:
	E107	E138	E176	E177	E227	E244	E264	E279	E315	E439
ChimeriVax-JE FRhL3 E279 Met	F	K	V	A	S	G	H	M	V	R
ChimeriVax-JE FRhL5 E279 Lys	F	K	V	A	S	G	H	K	V	R
JE SA14-14-2 PDKb (29b)	F	K	V	T	S	G	Q	M	V	R
JE SA14-14-2 PHKc (29a)	F	K	V	A	S	G	H	M	V	R
JE SA14 (1, 29b)	L	E	I	T	S	G	Q	K	A	K
JE Nakayama (22a)	L	E	I	T	P	E	Q	K	A	K

^aThe ChimeriVax-JE FRhL₃ and FRhL₅ viruses were sequenced across their entire genomes, and the mutation at E279 was the only difference found.

^bPDK, primary dog kidney cells.

^cPHK, primary hamster kidney cells.