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Risk of bias assessment of included RCTs
| Risk | Bias due to randomisation | Bias due to deviations from intended intervention | Bias due to missing outcome data | Bias in measurement of outcome | Bias in selection of the reported result | Overall |
|---|---|---|---|---|---|---|
| Low risk | 213 (40%) | 176(33%) | 451 (86%) | 151 (29%) | 390 (74%) | 58 (11%) |
| Some concerns | 292 (55%) | 317 (60%) | 68 (13%) | 346 (66%) | 135 (26%) | 184 (35%) |
| High risk | 22 (5%) | 34 (7%) | 8 (1%) | 30 (5%) | 2 (0%) | 285 (54%) |
